http://eyewiretoday.com/ Newest Articles en-us Sat, 19 May 2012 15:47:48 GMT Sat, 19 May 2012 15:47:48 GMT Eyetube.net http://eyewiretoday.com/view.asp?url=20120417-eating_nuts_can_help_stave_off_obesity_says_study Dieters often dismiss them because of their high fat content, but research suggests that snacking on nuts can help keep you slim. A study found that those who consumed varieties such as almonds, cashews and pistachios demonstrated a lower body weight, body mass index (BMI) and waist circumference compared to non-consumers. Tue, 17 Apr 2012 13:45:00 GMT http://eyewiretoday.com/view.asp?url=20120417-isomaltulose_doesnt_improve_glycemic_control_in_diabetes For patients with type 2 diabetes, substitution of sucrose with isomaltulose is not associated with improved glycemic control (measured by hemoglobin A1c [HbA1c] levels) at 12 weeks, according to a study published online April 9 in Diabetes Care. Stefanie Brunner, from the Technische Universitt Mnchen in Munich, Germany, and colleagues investigated whether replacement of sucrose with isomaltulose in sweet foods and drinks would improve metabolic control in type 2 diabetes. A total of 110 patient... Tue, 17 Apr 2012 13:43:00 GMT http://eyewiretoday.com/view.asp?url=20120417-meta-analysis_dulls_luster_of_metformin Metformin, the gold standard for treating type 2 diabetes, may not be so golden after all, researchers reported. A meta-analysis showed that the glucose-lowering agent had no effect on all-cause or cardiovascular mortality in people with diabetes, according to Catherine Cornu, MD, of the Clinical Investigation Centre in Lyon, France, and colleagues. Tue, 17 Apr 2012 13:43:00 GMT http://eyewiretoday.com/view.asp?url=20120417-ckd_predicts_mortality_in_diabetes Chronic kidney disease (CKD) as defined by higher serum creatinine or lower estimated glomerular filtration rate (eGFR) and/or the presence of proteinuria was found to be an important predictor of death in a review of 22 randomized controlled trials involving more than 90,000 adults with type 2 diabetes (J Am Heart Assoc. 2012;1:8-15). The studies were categorized into four groups according to annual mortality rates: <1, 1 to <2, 2 to < 4, and 4 per 100 patient-years. Mortality rates ... Tue, 17 Apr 2012 13:41:00 GMT http://eyewiretoday.com/view.asp?url=20120417-glp-1_is_a_good_choice_for_glycemic_control The top 3 drugs for the reduction of glycated hemoglobin A1c (A1C) levels are biphasic insulin, glucagon-like peptide 1 (GLP-1) analogs, and basal insulin. Although most oral antidiabetic drugs had a similar effect on A1C, GLP-1 analogs had the additional advantages of weight reduction in the absence of an increased risk for hypoglycemia. Sung-Chen Liu, MD, from the Mackay Memorial Hospital, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei, Taiwan, and colleagues... Tue, 17 Apr 2012 13:39:00 GMT http://eyewiretoday.com/view.asp?url=20120416-diabetes_linked_to_phthalates Phthalates, which are found in common plastics, cosmetics, and even some pharmaceuticals and medical devices, have been associated with the development of diabetes among seniors in Sweden, according to a study published online April 12 in Diabetes Care. Mon, 16 Apr 2012 14:06:00 GMT http://eyewiretoday.com/view.asp?url=20120416-study_links_mothers_weight_and_blood-sugar_levels_to_health_of_newborns Pregnant women with weight and blood-sugar levels even slightly above average may pose a risk to their pregnancies and the health of their newborns, a study suggests. The 2008 Hyperglycemia and Adverse Pregnancy Outcome study showed a possible link between mothers with elevated blood sugar but below the level of gestational diabetes and increased birth weight and elevated insulin in newborns. Mon, 16 Apr 2012 14:05:00 GMT http://eyewiretoday.com/view.asp?url=20120416-web-based_research_platform_identifies_five_significant_genetic_associations_for_hypothyroidism Using its unique online research platform, 23andMe, a leading personal genetics company, has found five significant genetic associations for hypothyroidism in the largest known genome-wide association study of hypothyroidism conducted to date. The details of the study are now available online in the journal PLoS ONE. Mon, 16 Apr 2012 14:02:00 GMT http://eyewiretoday.com/view.asp?url=20120416-irregular_or_not_enough_sleep_raises_diabetes_risk People who have irregular sleep patterns and/or do not sleep enough have a higher risk of developing metabolic syndrome and diabetes, researchers from Harvard Medical School, and Brigham and Women's Hospital in Boston, reported in the journal Science Translational Medicine. Orfeu Buxton, PhD. and team examined healthy volunteers over a 29-day period. They were made to sleep less and at varying bedtimes; sleeping patterns similar to those experienced by shift-workers. Mon, 16 Apr 2012 14:01:00 GMT http://eyewiretoday.com/view.asp?url=20120416-higher_hba1c_levels_predict_better_outcomes_in_advanced_heart_failure_with_diabetes Patients with advanced heart failure who were also diabetic had better two-year survival if their baseline glycated hemoglobin (HbA1c) levels were >7.3% in a new study [1]. Among the nondiabetic patients with heart failure, HbA1C levels did not predict survival outcomes. The retrospective cohort study is published online March 27, 2012 in the American Journal of Cardiology. Mon, 16 Apr 2012 13:59:00 GMT http://eyewiretoday.com/view.asp?url=20120412-cigarette_smoking_potentiates_effects_of_clopidogrel_in_diabetics Cigarette smoking enhanced the effects of clopidogrel in a study of diabetics with coronary artery disease. Accordingly, smokers were less like to experience high on-treatment platelet reactivity (HPR), the researchers reported in the March issue of JACC: Cardiovascular Interventions. "To the best of our knowledge the present investigation is the first pharmacodynamic study to examine and demonstrate the presence of a dose-response effect of smoking on clopidogrel effects in diabetic patients by... Thu, 12 Apr 2012 13:31:00 GMT http://eyewiretoday.com/view.asp?url=20120412-engineered_gut_bacteria_reverse_type_1_diabetes_in_experimental_mice Scientists have managed to reverse type 1 diabetes (T1D) in experimental mice by giving the animals an oral course of harmless gut bacteria that had been engineered to secrete the whole proinsulin autoantigen (PINS) and the immunomodulatory human cytokine IL-10 (hIL10). An international team led by scientists at the KU Leuven in Belgium, combined the engineered Lactococcus lactis therapy with a short, low-dose systemic course of the nonspecific immune modulating monoclonal antibody (mAb) anti-CD... Thu, 12 Apr 2012 13:30:00 GMT http://eyewiretoday.com/view.asp?url=20120412-lack_of_sleep_may_raise_risk_of_diabetes Your mother was right: regular bedtimes and a good night's sleep are good for you -- or at least, researchers reported, irregular bedtimes and not enough sleep are bad for you. In a 39-day experiment with healthy volunteers, shortened sleep time and varying bedtimes -- meant to mimic shift work -- led to impaired glucose regulation and metabolism, according to Orfeu Buxton, PhD, of Brigham and Women's Hospital in Boston, and colleagues. Thu, 12 Apr 2012 13:27:00 GMT http://eyewiretoday.com/view.asp?url=20120412-hard_arteries_more_likely_with_diabetes Patients with metabolic syndrome and diabetes are more likely to develop detectable levels of coronary artery calcium and to have greater progression of calcification compared with patients without those conditions, researchers found. Compared with individuals with neither condition, those with either or both of the conditions had a significantly greater risk of developing calcification in between cardiac CT scans (RRs 1.6 to 2.0), according to Nathan Wong, PhD, MPH, of the University of Califor... Thu, 12 Apr 2012 13:26:00 GMT http://eyewiretoday.com/view.asp?url=20120406-importance_of_diabetes_genetic_variants_unclear Genetic variants associated with type 2 diabetes that affect glucagon-like peptide 1 (GLP-1) are not associated with GLP-1 levels or GLP-1-induced insulin secretion in healthy individuals, according to a study published online March 28 in Diabetes. Fri, 6 Apr 2012 13:47:00 GMT http://eyewiretoday.com/view.asp?url=20120406-glaxo_to_seek_ok_for_diabetes_drug_after_trial_results GlaxoSmithKline PLC said it will push ahead with plans to file its experimental once-weekly diabetes drug albiglutide for regulatory approval, following the read-out from a series of clinical trials. The British company said top-line data from seven of eight late-stage Phase III clinical studies had now been received and, when taken together, support advancing albiglutide toward regulatory filings. Fri, 6 Apr 2012 13:46:00 GMT http://eyewiretoday.com/view.asp?url=20120406-the_antidepressant_effects_of_testosterone Testosterone, the primary male sex hormone, appears to have antidepressant properties, but the exact mechanisms underlying its effects have remained unclear. Nicole Carrier and Mohamed Kabbaj, scientists at Florida State University, are actively working to elucidate these mechanisms. They've discovered that a specific pathway in the hippocampus, a brain region involved in memory formation and regulation of stress responses, plays a major role in mediating testosterone's effects, according to the... Fri, 6 Apr 2012 13:44:00 GMT http://eyewiretoday.com/view.asp?url=20120406-link_discovered_between_estrogen_and_tobacco_smoke The hormone estrogen may help promote lung cancer - including compounding the effects of tobacco smoke on the disease - pointing towards potential new therapies that target the hormone metabolism, according to new research presented at the AACR Annual Meeting 2012 by scientists at Fox Chase Cancer Center in Philadelphia. "This research provides the link between estrogen and tobacco smoke," says study author Jing Peng, Ph.D., postdoctoral associate in the lab of Margie L. Clapper, Ph.D., also a c... Fri, 6 Apr 2012 13:43:00 GMT http://eyewiretoday.com/view.asp?url=20120406-levemir_assigned_more_reassuring_pregnancy_risk_category The US Food and Drug Administration (FDA) on March 29 gave insulin detemir (rDNA origin) injection (Levemir, Novo Nordisk) a more reassuring risk category for pregnant women with diabetes. Fri, 6 Apr 2012 13:42:00 GMT http://eyewiretoday.com/view.asp?url=20120406-once-daily_lixisenatide_effective_for_dm2 Monotherapy with the investigational GLP-1 receptor antagonist lixisenatide significantly reduces postprandial glucose excursions and HbA1c in treatment-naive type 2 diabetics, according to a new report. "No other placebo-controlled studies are available for GLP-1 receptor agonist monotherapy in a similar patient population," note Dr. Vivian A. Fonseca, with Tulane University Health Sciences Center in New Orleans, Louisiana, and colleagues in Diabetes Care online March 19. Fri, 6 Apr 2012 13:41:00 GMT http://eyewiretoday.com/view.asp?url=20120403-yogurt_drink_good_for_diabetes A Middle Eastern yogurt drink known as "doogh" and fortified with vitamin D was found to decrease inflammatory markers in people with type 2 diabetes, researchers found. Those who drank the doogh fortified with vitamin D, or vitamin D plus calcium, had decreased levels of highly sensitive C-reactive protein and several interleukin proteins, among other markers of inflammation, reported Tirang Neyestani, PhD, of Beheshti University of Medical Sciences in Tehran, Iran, and colleagues. Tue, 3 Apr 2012 13:43:00 GMT http://eyewiretoday.com/view.asp?url=20120403-weight_loss_and_fitness_may_enhance_mobility_in_diabetes An intensive lifestyle intervention to lower weight and improve fitness appeared to improve mobility among overweight patients with type 2 diabetes, according to the findings of a multicenter, randomized, controlled trial. W. Jack Rejeski, PhD, from Wake Forest University in Winston-Salem, North Carolina, and colleagues published their findings in the March 29 issue of the New England Journal of Medicine. Tue, 3 Apr 2012 13:40:00 GMT http://eyewiretoday.com/view.asp?url=20120403-gsk_receives_further_data_from_phase_3_studies_of_albiglutide_in_type_2_diabetes GlaxoSmithKline plc (GSK) announced that topline results have been received from seven of the eight Harmony Phase III studies investigating the use of albiglutide in type 2 diabetes. Albiglutide is an investigational once weekly glucagon-like peptide-1 (GLP-1) agonist. In Harmony 6, the second of the phase III Harmony studies to complete, albiglutide was compared to preprandial insulin, each administered on top of long-acting insulin glargine. In this study, the first of its kind for the class,... Tue, 3 Apr 2012 13:33:00 GMT http://eyewiretoday.com/view.asp?url=20120403-enteromedics_announces_25-year_diabetes_hypertension_and_weight_loss_data_from_the_maestro_rc_system_dm2_enable_study EnteroMedics Inc., the developer of medical devices using neuroblocking technology to treat obesity, metabolic diseases and other gastrointestinal disorders, today announced 2.5-year diabetes, hypertension and weight loss data from the Company's DM2 ENABLE Study of VBLOC vagal blocking therapy delivered via the Maestro Rechargeable (RC) System. A portion of the data will be presented at the 24th Annual Scientific Conference of the Obesity and Surgery Society of Australia and New Zealand being he... Tue, 3 Apr 2012 13:30:00 GMT http://eyewiretoday.com/view.asp?url=20120402-novo_nordisk_plans_to_move_ahead_with_once-weekly_diabetes_shot Novo Nordisk A/S is likely to proceed with development of a once-weekly version of its daily diabetes shot Victoza or a medicine from the same class to fend off competition from Amylin Pharmaceuticals Inc.s Bydureon. Chief Executive Officer Lars Soerensen is starting to open up to the idea, Mads Krogsgaard Thomsen, chief science officer, said in a March 30 interview at Novos headquarters in Bagsvaerd, a town outside Copenhagen. Mon, 2 Apr 2012 14:00:00 GMT